Warframe works just fine in Wine now.

All you need to do is add WINEDLLOVERRIDES=“xaudio2_7=n,b” %command% to the launch options in Steam.

※ If it asks you if it can defrag/reorganise your install files say no. Your file system should handle tha already, and when I had WF do it the game was super laggy since, and I had to reinstall :(

These are the controls I use; a bit different from the default. These settings don't seem to stick round if you reinstall, so keeping them here for my own reference.